由于耐药/结瘤/分裂外排泵家族的一个成员，淋病奈瑟菌对脊椎动物抗菌肽的敏感性受到调节。
Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family.
作者信息
Shafer W M, Qu X, Waring A J, Lehrer R I
机构信息
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1829-33. doi: 10.1073/pnas.95.4.1829.
Abstract
We have previously described the antibacterial capacity of protegrin-1 (PG-1), a cysteine-rich, cationic peptide from porcine leukocytes, against Neisseria gonorrhoeae. We now report genetic and biochemical evidence that gonococcal susceptibility to the lethal action of PG-1 and other structurally unrelated antibacterial peptides, including a peptide (LL-37) that is expressed constitutively by human granulocytes and testis and inducibly by keratinocytes, is modulated by an energy-dependent efflux system termed mtr. These results indicate that such efflux systems may enable mucosal pathogens like gonococci to resist endogenous antimicrobial peptides that are thought to act during infection.
摘要
我们之前曾描述过防御素-1（PG-1）的抗菌能力，它是一种来自猪白细胞的富含半胱氨酸的阳离子肽，对淋病奈瑟菌具有抗菌作用。我们现在报告基因和生化证据，表明淋病奈瑟菌对PG-1及其他结构不相关抗菌肽（包括一种由人类粒细胞和睾丸组成性表达、角质形成细胞诱导性表达的肽LL-37）致死作用的敏感性，受一种称为mtr的能量依赖性外排系统调控。这些结果表明，此类外排系统可能使淋病奈瑟菌等黏膜病原体能够抵抗被认为在感染过程中起作用的内源性抗菌肽。
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The MtrD protein of Neisseria gonorrhoeae is a member of the resistance/nodulation/division protein family constituting part of an efflux system.淋病奈瑟菌的MtrD蛋白是构成外排系统一部分的耐药/结瘤/分裂蛋白家族的成员。
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