Hughes J R, Rechitsky I
University of Illinois Medical Center, Chicago 60612-7330, USA.
Clin Electroencephalogr. 1996 Oct;27(4):187-90.
Thirty patients with possible demyelinating disease or visual system disorder were referred for Visual Evoked Potentials (VEP) and had abnormal flash (FL) but normal pattern reversal (PR) responses. Patients with confirmed organic brain disorders had significantly longer latencies to P100 from FL than in the unconfirmed group, but the subgroup, later proven to have demyelinating disease had the most significantly abnormal latencies to FL. Even the PR responses, although within normal limits, showed significantly longer latencies in the organic brain disorder group, compared to the unconfirmed group. For patients who could be followed-up, 45% of them proved to have demyelinating disease. A visual disorder was confirmed in 53% and an organic brain disorder in an additional 13%, so that 2/3 of all patients had one of the latter two conditions. These data argue for the use of flash, in addition to the pattern reversal stimulus, in the protocol for visual evoked potentials.
30名可能患有脱髓鞘疾病或视觉系统障碍的患者接受了视觉诱发电位（VEP）检查，其闪光（FL）反应异常，但图形翻转（PR）反应正常。确诊为器质性脑疾病的患者，其FL诱发的P100潜伏期明显长于未确诊组，但后来被证实患有脱髓鞘疾病的亚组，其FL潜伏期异常最为明显。即使PR反应在正常范围内，与未确诊组相比，器质性脑疾病组的潜伏期也明显更长。对于能够进行随访的患者，45%被证实患有脱髓鞘疾病。53%的患者确诊为视觉障碍，另有13%确诊为器质性脑疾病，因此所有患者中有2/3患有后两种疾病之一。这些数据表明，在视觉诱发电位检查方案中，除了图形翻转刺激外，还应使用闪光刺激。
