Matsuura M, Yoshino M, Onda H, Kojima T
Department of Neuropsychiatry, Nihon University School of Medicine, Tokyo, Japan.
Clin Electroencephalogr. 1996 Oct;27(4):202-9.
Nineteen chronic schizophrenics (8 males and 11 females) showed at least one spike and wave complex (SpW) in their rested-awake EEGs during long-term neuroleptic treatment. The age at the first appearance of the SpW ranged from 16 to 60 years, and the duration of neuroleptic medication preceding its appearance was from 1 to 35 years. Two types of SpW waveform were discriminated; one was a diffuse high voltage isolated 3.5-4 Hz SpW complex, and the other a diffuse moderate voltage 5-6 Hz SpW burst. In EEG studies repeated over the long-term, the presence of SpW was transient in 11 cases, intermittent in 5 cases, and continuous in 3 cases. Three patients had generalized tonic-clonic clinical seizures; two of their EEGs did not show SpW until after the onset of seizures. All three responded well to adjunctive anticonvulsant therapy. The other 16 patients exhibited SpW but did not have clinical seizures with or without prophylactic use of anticonvulsants. The SpW in the EEG of chronic schizophrenics might be an indicator of predisposition for seizure, but it is not a good predictor of seizure.
19名慢性精神分裂症患者（8名男性和11名女性）在长期使用抗精神病药物治疗期间，静息清醒脑电图（EEG）显示至少有一次棘慢复合波（SpW）。SpW首次出现的年龄在16至60岁之间，其出现前抗精神病药物治疗的持续时间为1至35年。区分出两种类型的SpW波形；一种是弥漫性高电压孤立的3.5 - 4Hz SpW复合波，另一种是弥漫性中等电压的5 - 6Hz SpW爆发。在长期重复进行的EEG研究中，SpW的出现情况为11例是短暂性的，5例是间歇性的，3例是持续性的。3名患者出现全身性强直阵挛性临床癫痫发作；其中2例在癫痫发作开始后EEG才显示出SpW。所有3例对辅助抗惊厥治疗反应良好。另外16例患者出现SpW，但无论是否预防性使用抗惊厥药物均未出现临床癫痫发作。慢性精神分裂症患者EEG中的SpW可能是癫痫易感性的一个指标，但它并非癫痫的良好预测指标。
