Noguchi E, Shibasaki M, Arinami T, Takeda K, Kobayashi K, Matsui A, Hamaguchi H
Department of Pediatrics, University of Tsukuba, Ibaraki-ken, Japan.
Genomics. 1998 Jan 1;47(1):121-4. doi: 10.1006/geno.1997.5054.
Susceptibility to the development of asthma and other atopic diseases is known to be associated with genetic components, and several candidate genes have been reported to be linked to atopy and asthma. We have examined a linkage between traits of specific IgE responses to the house dust mite and its purified allergens, high total serum IgE levels and asthma, and the markers at the T-cell receptor (TCR) alpha chain gene (TCR-alpha) and beta chain gene (TCR-beta) in Japanese families ascertained through asthmatic children. Affected sib-pair analyses provided evidence for linkage between TCR-beta and nearby markers (D7S684) on chromosome 7q35 and both IgE and asthmatic phenotypes, but no evidence for linkage of IgE responses nor asthma phenotype to TCR-alpha was detected. The results suggest the presence of major gene(s) controlling atopy and asthma susceptibility in TCR-beta and the nearby region.
已知哮喘及其他特应性疾病的易感性与遗传因素相关，并且已有多项候选基因被报道与特应性和哮喘有关。我们通过哮喘患儿确定了一些日本家庭，对其进行研究，以检测对屋尘螨及其纯化变应原的特异性IgE反应性状、高血清总IgE水平和哮喘与T细胞受体（TCR）α链基因（TCR-α）和β链基因（TCR-β）上的标记之间的连锁关系。受累同胞对分析为7号染色体7q35上的TCR-β及附近标记（D7S684）与IgE和哮喘表型之间的连锁提供了证据，但未检测到IgE反应或哮喘表型与TCR-α连锁的证据。结果表明在TCR-β及其附近区域存在控制特应性和哮喘易感性的主要基因。
