引起尿路感染的病原体对喹诺酮类药物的耐药性。

Resistance to quinolones in pathogens causing urinary tract infections.

作者信息

Kapoor H, Aggarwal P

机构信息

Department of Microbiology, Safdarjang Hospital, New Delhi.

出版信息

J Commun Dis. 1997 Sep;29(3):263-7.

PMID:9465532

Abstract

157 bacterial isolates from cases with urinary tract infections (UTI) were studied for their susceptibility to some of the available quinolones as compared to other commonly used antimicrobial agents in UTI. Resistance to nalidixic acid was observed in 62.4% of isolates whereas for pefloxacin, norfloxacin, ciprofloxacin and lomifloxacin it was 54.7%, 52.5%, 51.5% and 50.3% respectively. Aminoglycosides and third generation cephalosporins showed resistance in fewer isolates. Gentamicin resistance was observed in 21% and corresponding figure for amikacin, cefotaxime and ceftriaxone was 7%, 8.9% and 12.1% respectively. Nitrofurantoin showed resistance in 36.3% of isolates and 48% isolates were resistant to cephalexin. The minimum inhibitory concentration (MIC) of quinolones was more than 64 mcg/ml which is > 8 times in resistant strains as compared to sensitive isolates.

摘要

对157株来自尿路感染（UTI）病例的细菌分离株进行了研究，以观察它们对一些现有喹诺酮类药物的敏感性，并与UTI中其他常用抗菌药物进行比较。62.4%的分离株对萘啶酸耐药，而对培氟沙星、诺氟沙星、环丙沙星和洛美沙星的耐药率分别为54.7%、52.5%、51.5%和50.3%。氨基糖苷类和第三代头孢菌素的耐药分离株较少。庆大霉素耐药率为21%，阿米卡星、头孢噻肟和头孢曲松的相应耐药率分别为7%、8.9%和12.1%。呋喃妥因耐药率为36.3%，48%的分离株对头孢氨苄耐药。喹诺酮类药物的最低抑菌浓度（MIC）在耐药菌株中超过64 mcg/ml，是敏感分离株的8倍以上。