Kageshita T, Nishimura Y, Nakata H, Terashima M, Kajiura T, Maeda H, Yokoyama M
Department of Respiratory Disease, Takatsuki General Hospital, Osaka, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Oct;35(10):1035-9.
To determine the relationship between airway and coronary artery spasmogenesity in patients with vasospastic angina pectoris (VSAP), we measured the bronchial responsiveness to inhaled methacholine in 21 VSAP patients (V-group) and compared it to that of 17 chest pain syndrome patients with normal coronary (N-group). In the V-group, logarithmic values of the minimum cumulative dose required to decrease respiratory conductance from the baseline (Log Dmin) was significantly lower than that in N-group (0.47 +/- 0.60 log units vs. 0.98 +/- 0.60 log units respectively, p < 0.05). Log Dmin was significantly correlated with the dose of acetylcholine which induced a greater than 90% stenosis of the coronary artery (r = 0.383, p < 0.05). We concluded that both the coronary artery and the airway show hyperresponsiveness to cholinergic agonists in patients with VSAP.
为了确定变异性心绞痛（VSAP）患者气道与冠状动脉痉挛发生性之间的关系，我们测量了21例VSAP患者（V组）对吸入乙酰甲胆碱的支气管反应性，并将其与17例冠状动脉正常的胸痛综合征患者（N组）进行比较。在V组中，使呼吸传导率从基线下降所需的最小累积剂量的对数值（Log Dmin）显著低于N组（分别为0.47±0.60对数单位和0.98±0.60对数单位，p<0.05）。Log Dmin与诱导冠状动脉狭窄超过90%的乙酰胆碱剂量显著相关（r = 0.383，p<0.05）。我们得出结论，VSAP患者的冠状动脉和气道对胆碱能激动剂均表现出高反应性。
