Shimizu K, Shiota S, Nakaya Y, Sakamoto K, Iwase A, Aoki S, Matsuoka R, Nagayama T, Kawabata Y
Department of Respiratory Medicine, Showa General Hospital, Tokyo, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Oct;35(10):1099-103.
A 26-year-old woman was admitted to our hospital because of dyspnea and fever one day after taking medicines for the common cold. A chest roentgenogram and a computed tomogram revealed diffuse patchy infiltrates in both lung fields. Examination of a specimen obtained by transbronchial lung biopsy showed thickening of alveolar walls and infiltration of eosinophils. Bronchoalveolar lavage fluid had many eosinophils. DLST was positive for Bufferin, which the patient took one day before the dyspnea and fever began. We believe that this patient's pulmonary disease was caused by Bufferin. We should realize that this widely used analgesic can cause acute eosinophilic lung disease. The patient was not given corticosteroids, and her condition improved soon after she stopped taking Bufferin.
一名26岁女性在服用感冒药一天后因呼吸困难和发热入住我院。胸部X线片和计算机断层扫描显示双肺野弥漫性斑片状浸润。经支气管肺活检获取的标本检查显示肺泡壁增厚和嗜酸性粒细胞浸润。支气管肺泡灌洗液中有许多嗜酸性粒细胞。药物淋巴细胞刺激试验显示该患者服用的百服宁呈阳性,她在出现呼吸困难和发热前一天服用了该药。我们认为该患者的肺部疾病是由百服宁引起的。我们应该认识到这种广泛使用的镇痛药可导致急性嗜酸性粒细胞性肺病。该患者未给予皮质类固醇,在停止服用百服宁后病情很快好转。