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[一例肺动静脉瘘未经治疗持续一段时间后表现为多发性脑脓肿的病例]

[A case of pulmonary arteriovenous fistula presenting as multiple brain abscesses after a sustained period without treatment].

作者信息

Yoshida Y, Harada S, Arai N, Matsui S, Maruyama M, Kobayashi M

机构信息

First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.

出版信息

Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Oct;35(10):1104-7.

PMID:9465623
Abstract

A 64-year-old man was admitted to our hospital with multiple brain abscesses accompanied by pulmonary arteriovenous fistula (PAVF). He had been diagnosed with PAVF eight years previously, but had refused any treatment despite a developing exertional dyspnea. Rendu-Osler-Weber disease was diagnosed as well because the patient exhibited teleangiectasis of the nasopharyngeal mucosa and persistent gastro-intestinal bleeding. Despite administration of antibiotics and corticosteroids the abscesses perforated into the lateral ventricle. The natural history of this rare disease is still incompletely understood. Thus, the time at which treatment should be commenced remains unclear. However the natural course of PAVF is unsatisfactory, and it appears that treatment by surgery and/or embolization should be considered in all cases.

摘要

一名64岁男性因多发性脑脓肿伴肺动静脉瘘(PAVF)入住我院。他八年前被诊断为PAVF,尽管出现了劳力性呼吸困难,但一直拒绝接受任何治疗。由于患者出现鼻咽部黏膜毛细血管扩张和持续性胃肠道出血,也被诊断为遗传性出血性毛细血管扩张症(Rendu-Osler-Weber病)。尽管使用了抗生素和皮质类固醇,脓肿仍穿破进入侧脑室。这种罕见疾病的自然史仍未完全明了。因此,开始治疗的时机仍不明确。然而,PAVF的自然病程并不理想,似乎在所有病例中都应考虑手术和/或栓塞治疗。

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