Kondo K
Department of Microbiology, Osaka University Medical School.
Nihon Rinsho. 1998 Jan;56(1):83-9.
Human cytomegalovirus(CMV) is a significant pathogen in immunocompromised individuals and neonates. Human herpesvirus 6(HHV-6) is a causative agent of exanthem subitum. These two viruses belong to beta-herpesvirus subfamily. Latency, a hallmark of all herpesvirus, remains poorly understood for beta-herpesvirus. We investigate maintenance and expression of the vira genome in an experimental latent infection using granulocyte-macrophage progenitors(GM-Ps) for CMV and monocytes/macrophages for HHV-6. To better understand beta-herpesvirus latency, we investigate the extent of viral gene expression in our latency system and found two novel classes of CMV latency associated transcripts(CLTs). Latent infection by CMV is accompanied by the presence of latency-associated transcripts and expression of immunogenic proteins. It is suggested that bone marrow-derived myeloid progenitors are an important natural site of CMV latency and peripheral blood derived monocytes/macrophages is important to maintain HHV-6 latency.
人巨细胞病毒（CMV）是免疫功能低下个体和新生儿中的一种重要病原体。人疱疹病毒6型（HHV-6）是幼儿急疹的病原体。这两种病毒属于β-疱疹病毒亚科。潜伏期是所有疱疹病毒的一个标志，对于β-疱疹病毒来说，人们对其了解仍然很少。我们使用粒细胞-巨噬细胞祖细胞（GM-Ps）来研究CMV的实验性潜伏感染以及使用单核细胞/巨噬细胞来研究HHV-6的实验性潜伏感染中病毒基因组的维持和表达。为了更好地理解β-疱疹病毒的潜伏期，我们研究了我们的潜伏系统中病毒基因表达的程度，并发现了两类新的CMV潜伏相关转录本（CLTs）。CMV的潜伏感染伴随着潜伏相关转录本的存在和免疫原性蛋白的表达。有人提出，骨髓来源的髓系祖细胞是CMV潜伏的一个重要天然位点，而外周血来源的单核细胞/巨噬细胞对于维持HHV-6的潜伏很重要。
