Shiraki K, Yukawa T, Kurokawa M, Kageyama S
Department of Virology, Toyama Medical and Pharmaceutical University.
Nihon Rinsho. 1998 Jan;56(1):156-60.
Medicinal herbs, Geum japonicum, Syzygium aromaticum, Terminalia chebula, and Rhus javanica, with anti-herpes simplex virus therapeutic activity, inhibited replication of human cytomegalovirus(CMV) and murine CMV(MCMV) in vitro. These anti-CMV activities were examined in an MCMV infection model using immunosuppressed mice. Geum japonicum, Syzygium aromaticum, and Terminalia chebula significantly suppressed MCMV yields in lungs of treated mice compared with water treatment. Efficacy of oral treatment with 750 mg/kg/day of Geum japonicum-extract was similar to that of the intraperitoneal administration with 2 mg/kg/day of ganciclovir in increasing the body weight of infected mice and reducing the virus yield in the lungs. These herbs may be beneficial for the prophylaxis of CMV diseases in immunocompromized patients.
具有抗单纯疱疹病毒治疗活性的草药，如柔毛水杨梅、丁香、诃子和盐肤木，在体外可抑制人巨细胞病毒（CMV）和鼠巨细胞病毒（MCMV）的复制。在使用免疫抑制小鼠的MCMV感染模型中检测了这些抗CMV活性。与水处理相比，柔毛水杨梅、丁香和诃子显著抑制了治疗小鼠肺部的MCMV产量。在增加感染小鼠体重和降低肺部病毒产量方面，每天口服750 mg/kg的柔毛水杨梅提取物的疗效与每天腹腔注射2 mg/kg的更昔洛韦相似。这些草药可能对免疫功能低下患者预防CMV疾病有益。
