Schultze-Werninghaus G, Gonsior E, Thiel C, Kroidl R, Meier-Sydow J
Acta Allergol. 1976 Feb;31(1):44-60.
355 out-patients with signs of bronchial asthma were studied with special reference to animal dander sensitization. Case histories allowed the clinical diagnosis of an allergy to animal dander in 75 patients (21.1%). Skin testing is a useful means, as large reactions appear in most cases of animal dander allergy (60.7% are greater than or equal to + + + -reactions). Skin reactions, however, often are "false positive" or "false negative". Therefore, bronchial provocation tests are necessary if the case history is doubtful and/or the skin reaction is less than a + + + -reaction. There is a positive correlation between skin reaction and bronchial provocation test. No negative inhalation tests were seen when the skin reaction was greater than + + +. However, a positive inhalation test can be correlated with a negative or weakly positive skin test. The probability of common structural properties of different mammalian dander allergens is discussed. Avoidance of exposure to the animal is recommended as the therapy of choice.
对355名有支气管哮喘症状的门诊患者进行了研究，特别关注动物皮屑致敏情况。病历显示，75名患者（21.1%）临床诊断对动物皮屑过敏。皮肤试验是一种有用的方法，因为在大多数动物皮屑过敏病例中会出现强烈反应（60.7%为大于或等于 + + + 反应）。然而，皮肤反应常常出现“假阳性”或“假阴性”。因此，如果病历存疑和/或皮肤反应小于 + + + 反应，则需要进行支气管激发试验。皮肤反应与支气管激发试验之间存在正相关。当皮肤反应大于 + + + 时，未出现阴性吸入试验。然而，阳性吸入试验可能与阴性或弱阳性皮肤试验相关。讨论了不同哺乳动物皮屑过敏原具有共同结构特性的可能性。建议避免接触动物作为首选治疗方法。
