McCartan B E, McCreary C E
Department of Oral Surgery, Oral Medicine and Oral Pathology, School of Dental Science, Trinity College Dublin 2, Ireland.
Oral Dis. 1997 Jun;3(2):58-63. doi: 10.1111/j.1601-0825.1997.tb00013.x.
To identify, from amongst drugs reported as causing lichenoid drug eruptions, those affecting the oral mucous membranes and to review the clinical, histological and immunological features of such oral lichenoid drug eruptions in comparison to oral lichen planus, amalgam contact lesions and lichen planus-like eruption in graft-versus-host disease (GVHD).
Ovid Medline data searches on CD-Rom were carried out for the years 1966-1996 to identify reports of oral lichenoid drug eruptions and their clinical, histological and immunological features. Articles retrieved were examined for further appropriate references in the period 1940-1996.
Each paper was critically examined for evidence of a clinically verifiable lichenoid drug-eruption affecting the oral mucous membranes and the effects of subsequent drug withdrawal. Available clinical, histological and immunological features were recorded. The papers examined were too diverse in nature to permit a structured criticism. The extracted data have been tabulated where appropriate.
The reports of oral lichenoid drug eruptions are considerably fewer than those of cutaneous eruptions and fewer drugs have been reported as causing oral rather than cutaneous lichenoid eruptions. Histology and immunology cannot be used reliably to differentiate lichenoid drug eruptions from idiopathic lichen planus, amalgam contact lesions and lichen planus-like eruption in GVHD. Lichenoid drug eruptions may also show some histological characteristics of oral discoid lupus erythematosus. An accepted protocol agreed by a number of international centres would permit the gathering of substantial information on LDE and could lead to a greater understanding of the mechanisms involved.
从报告可引起苔藓样药疹的药物中，识别出那些影响口腔黏膜的药物，并比较此类口腔苔藓样药疹与口腔扁平苔藓、汞合金接触性损害及移植物抗宿主病（GVHD）中的扁平苔藓样皮疹的临床、组织学和免疫学特征。
对1966年至1996年期间CD-ROM上的Ovid Medline数据进行检索，以识别口腔苔藓样药疹的报告及其临床、组织学和免疫学特征。对检索到的文章在1940年至1996年期间进一步查找合适的参考文献。
对每篇论文进行严格审查，以寻找影响口腔黏膜的临床可证实的苔藓样药疹证据以及后续停药的效果。记录现有的临床、组织学和免疫学特征。所审查的论文性质差异太大，无法进行结构化批评。提取的数据已在适当处制成表格。
口腔苔藓样药疹的报告比皮肤药疹的报告少得多，且报告可引起口腔而非皮肤苔藓样药疹的药物也较少。组织学和免疫学不能可靠地用于区分苔藓样药疹与特发性扁平苔藓、汞合金接触性损害及GVHD中的扁平苔藓样皮疹。苔藓样药疹也可能表现出口腔盘状红斑狼疮的一些组织学特征。由多个国际中心商定的公认方案将有助于收集有关盘状红斑狼疮的大量信息，并可能加深对其相关机制的理解。
