Corneal ulcer associated with deposits of norfloxacin.
作者信息
Konishi M, Yamada M, Mashima Y
机构信息
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
出版信息
Am J Ophthalmol. 1998 Feb;125(2):258-60. doi: 10.1016/s0002-9394(99)80104-4.
PURPOSE
To report a case of corneal ulcer associated with deposits of norfloxacin.
METHOD
Case report. A 40-year-old man with right trigeminal and facial nerve palsies and decreased tear secretion developed a corneal ulcer with white deposits in the right eye. The deposits were removed and analyzed by high-performance liquid chromatography.
RESULTS
High-performance liquid chromatography results disclosed that the deposits on the corneal surface had the same retention time as norfloxacin. The patient discontinued norfloxacin ophthalmic solution and recovered successfully.
CONCLUSION
Clinicians should be aware that frequent applications of topical norfloxacin in patients with decreased tear secretion may result in deposition of the drug on the cornea.
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