Konishi M, Yamada M, Mashima Y
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Am J Ophthalmol. 1998 Feb;125(2):258-60. doi: 10.1016/s0002-9394(99)80104-4.
To report a case of corneal ulcer associated with deposits of norfloxacin.
Case report. A 40-year-old man with right trigeminal and facial nerve palsies and decreased tear secretion developed a corneal ulcer with white deposits in the right eye. The deposits were removed and analyzed by high-performance liquid chromatography.
High-performance liquid chromatography results disclosed that the deposits on the corneal surface had the same retention time as norfloxacin. The patient discontinued norfloxacin ophthalmic solution and recovered successfully.
Clinicians should be aware that frequent applications of topical norfloxacin in patients with decreased tear secretion may result in deposition of the drug on the cornea.
报告1例与诺氟沙星沉积相关的角膜溃疡病例。
病例报告。1名40岁男性，患有右侧三叉神经和面神经麻痹，泪液分泌减少，右眼出现角膜溃疡并伴有白色沉积物。取出沉积物并通过高效液相色谱法进行分析。
高效液相色谱分析结果显示，角膜表面的沉积物与诺氟沙星具有相同的保留时间。患者停用诺氟沙星滴眼液后成功康复。
临床医生应注意，泪液分泌减少的患者频繁局部应用诺氟沙星可能导致药物在角膜上沉积。
