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[胱胺对谷胱甘肽系统状态的影响]

[Effects of cystamine on the state of glutathione system].

作者信息

Grebeniuk A N, Udintsev A V

机构信息

Military Medical Academy, St. Petersburg.

出版信息

Radiats Biol Radioecol. 1997 Nov-Dec;37(6):905-9.

PMID:9467645
Abstract

The action of cystamine on the glutathione system state in the erythrocytes of the peripheral blood, in the tissues of the brain and liver of the rats are studied. It was shown that the most changes in the glutathione content and activity of the glutathione metabolism enzymes are seen in the brain on the height of the cystamine protective action. The high concentration of reduced forms of the glutathione and the increasing activity of the glutathione peroxidase held in the liver for 5-th days after the intraperitoneal injection of the cystamine.

摘要

研究了胱胺对大鼠外周血红细胞、脑和肝脏组织中谷胱甘肽系统状态的作用。结果表明,在胱胺发挥保护作用的高峰期,脑中谷胱甘肽含量和谷胱甘肽代谢酶活性的变化最为明显。腹腔注射胱胺后第5天,肝脏中还原型谷胱甘肽浓度较高,谷胱甘肽过氧化物酶活性增加。

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