在妊娠中期使用尿游离β-人绒毛膜促性腺激素筛查唐氏综合征。

Screening for Down syndrome using urine hCG free beta-subunit in the second trimester of pregnancy.

作者信息

Cole L A, Jacobs M, Isozaki T, Palomaki G E, Bahado-Singh R O, Mahoney M J

机构信息

Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA.

出版信息

Prenat Diagn. 1997 Dec;17(12):1107-11. doi: 10.1002/(sici)1097-0223(199712)17:12<1107::aid-pd199>3.0.co;2-a.

DOI:10.1002/(sici)1097-0223(199712)17:12<1107::aid-pd199>3.0.co;2-a

PMID:9467807

Abstract

Human chorionic gonadotropin (hCG) free beta-subunit levels were determined in 709 control and 13 Down syndrome urine samples from the second trimester of pregnancy. Results were normalized to urine creatinine concentration and converted to multiples of the unaffected pregnancy medium (MOM). The concentration of free beta-subunit in Down syndrome cases was 3.9 MOM. Seven of 13 Down syndrome pregnancies (54 per cent) had free beta-subunit levels at or above the 95th centile of unaffected pregnancies. Urine free beta-subunit may potentially be useful as a screening test for Down syndrome.

摘要

测定了709份对照尿液样本和13份孕中期唐氏综合征孕妇尿液样本中的人绒毛膜促性腺激素（hCG）游离β亚基水平。结果根据尿肌酐浓度进行了标准化处理，并换算成未受影响妊娠介质的倍数（MOM）。唐氏综合征病例中游离β亚基的浓度为3.9MOM。13例唐氏综合征妊娠中有7例（54%）的游离β亚基水平处于或高于未受影响妊娠的第95百分位数。尿游离β亚基有可能作为唐氏综合征的一种筛查检测手段。