Ismaeel N A
Department of Microbiology, College of Medicine and Allied Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Microbios. 1997;91(367):97-103.
An agar dilution technique and the 'E' test were used to compare the antimicrobial activities of ticarcillin, ticarcillin-clavulanate, ampicillin, ampicillin-sulbactam, piperacillin, piperacillin-tazobactam, meropenem, biapenem, imipenem, levofloxacin, ofloxacin, ciprofloxacin, ceftazidime and cefepime against 97 clinical isolates of Xanthomonas maltophilia. Intermediate susceptibility breakpoints for members of the family Enterobacteriaceae were used. Results were analysed as minimum inhibitory concentrations for 50 and 90% of the strains tested and as percentages of strains susceptible at the breakpoint. Good correlation between the two techniques was observed, with ticarcillin-clavulanate clearly the most active agent by both methods with 64 to 66% followed by levofloxacin with 63 to 65% of the strains being susceptible. Biapenem and imipenem showed weak activity with none of the strains being susceptible. Ceftazidime had better activity than cefepime when they were compared by the two methods. There was no significant difference in the results between the two susceptibility techniques used.
采用琼脂稀释法和“E”试验，比较替卡西林、替卡西林-克拉维酸、氨苄西林、氨苄西林-舒巴坦、哌拉西林、哌拉西林-他唑巴坦、美罗培南、比阿培南、亚胺培南、左氧氟沙星、氧氟沙星、环丙沙星、头孢他啶和头孢吡肟对97株嗜麦芽窄食单胞菌临床分离株的抗菌活性。采用肠杆菌科成员的中度敏感折点。结果分析为受试菌株50%和90%的最低抑菌浓度以及折点处敏感菌株的百分比。观察到两种技术之间具有良好的相关性，替卡西林-克拉维酸显然是两种方法中活性最强的药物，64%至66%的菌株敏感，其次是左氧氟沙星，63%至65%的菌株敏感。比阿培南和亚胺培南活性较弱，无菌株敏感。两种方法比较时，头孢他啶的活性优于头孢吡肟。所采用的两种药敏技术的结果无显著差异。
