Sartor R B
University of North Carolina School of Medicine, Department of Medicine/Division of Digestive Diseases, Chapel Hill 27599-7080, USA.
Aliment Pharmacol Ther. 1997 Dec;11 Suppl 3:89-96; discussion 96-7. doi: 10.1111/j.1365-2036.1997.tb00813.x.
New rodent models of chronic intestinal inflammation are mediated by a TH1-cell and macrophage dominated immune response to luminal bacterial constituents. The pathology of these spontaneous and induced models differ widely and caution is needed when assessing the comparative aspects of such animal models and human inflammatory bowel diseases (IBD). Considerable immunological and therapeutic evidence suggests that chronic and immune-mediated models are relevant in human IBD and that pathogenic principles are similar. However, animal models have not been able to duplicate exactly the pathological characteristics of ulcerative colitis or Crohn's disease, indicating a need for caution in extrapolating data from experimental models to human IBD.
新的慢性肠道炎症啮齿动物模型是由对肠腔细菌成分的TH1细胞和巨噬细胞主导的免疫反应介导的。这些自发和诱导模型的病理学差异很大，在评估此类动物模型与人类炎症性肠病（IBD）的比较方面时需要谨慎。大量的免疫学和治疗学证据表明，慢性和免疫介导的模型与人类IBD相关，且致病原理相似。然而，动物模型尚未能够完全复制溃疡性结肠炎或克罗恩病的病理特征，这表明在将实验模型的数据外推至人类IBD时需要谨慎。
Zotero 插件