Koonin E V, Galperin M Y
National Center for Biotechnology Information, National Library of Medicine, National Institute of Health, Bethesda, Maryland 20894, USA.
Curr Opin Genet Dev. 1997 Dec;7(6):757-63. doi: 10.1016/s0959-437x(97)80037-8.
Comparative analysis of the complete sequences of seven bacterial and three archaeal genomes leads to the first generalizations of emerging genome-based microbiology. Protein sequences are, generally, highly conserved, with -70% of the gene products in bacteria and archaea containing ancient conserved regions. In contrast, there is little conservation of genome organization, except for a few essential operons. The most striking conclusions derived by comparison of multiple genomes from phylogenetically distant species are that the number of universally conserved gene families is very small and that multiple events of horizontal gene transfer and genome fusion are major forces in evolution.
对七个细菌基因组和三个古细菌基因组的完整序列进行比较分析，得出了基于基因组的新兴微生物学的首批一般性结论。一般来说，蛋白质序列高度保守，细菌和古细菌中70%的基因产物含有古老的保守区域。相比之下，除了少数必需操纵子外，基因组组织几乎没有保守性。通过比较系统发育上距离较远物种的多个基因组得出的最惊人结论是，普遍保守的基因家族数量非常少，水平基因转移和基因组融合的多个事件是进化中的主要力量。
