Pollice L, Resta L, Simone G
Ric Clin Lab. 1979 Jul-Sep;9(3):273-8. doi: 10.1007/BF02932179.
Argyrophilia and argentaffinity, as basic properties of APUD cells, were investigated in 50 normal and hyperplastic prostates, which included both autopsy and surgical specimens from patients of various ages. Normal prostates (including glands from 3 foetuses) had 62% of argyrophil-positive granules in the glandular epithelia, while only 44% of the hyperplastic glands were positive. Argentaffin-positive cells were found in 12% of the surgical hyperplastic cases. Both argyrophil and argentaffin cells were distributed in zones, often in lobule-like shapes, lying along the basal membrane. On the basis of these findings, there is a discussion on the possible roles played by the so-called APUD cells in hyperplastic and neoplastic growths of the prostate, such as carcinoid tumours (apudomas) or endocrine-associated syndromes in the course of prostatic cancer.
对50例正常及增生前列腺组织（包括不同年龄段患者的尸检和手术标本）进行了研究，探讨了嗜银性和亲银性这两种APUD细胞的基本特性。正常前列腺组织（包括3例胎儿的腺体）中，腺上皮内62%的细胞有嗜银阳性颗粒，而增生腺体中仅有44%呈阳性。在12%的手术增生病例中发现了亲银阳性细胞。嗜银细胞和亲银细胞均呈区域分布，常呈小叶状，沿基底膜排列。基于这些发现，对所谓的APUD细胞在前列腺增生和肿瘤生长（如类癌肿瘤（APUD瘤）或前列腺癌病程中的内分泌相关综合征）中可能发挥的作用进行了讨论。
