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儿茶酚胺在兔促性腺激素释放中的作用。

Role of catecholamines in release of gonadotrophic hormones in the rabbit.

作者信息

Przekop F, Domański E

出版信息

Acta Physiol Pol. 1976 Mar-Apr;27(2):163-8.

PMID:946931
Abstract

Role of catecholamines (CA) in transmission of neurohormone releasing gonadotrophin (GnHR) from the hypothalamus to hypophysis was estimated on the basis of the hypothalamic catecholaminergic system blockade with 6-hydroxydopamine (6-OHDA) and intraventricular infusions of CA in the rabbit. 6-OHDA administered intraventricularly in doses 200-500 mug caused temporary blockade of ovulation. Intraventricular infusion of noradrenaline (NA) induced ovulation in 50% of animals tested, whereas dopamine (DA) and adrenaline (A), induced ovulation only in very few cases. It seems, that catecholaminergic system participates in transmission of neurohormones to the hypophysis, and NA plays the most important role in this process.

摘要

基于用6-羟基多巴胺(6-OHDA)阻断下丘脑儿茶酚胺能系统以及对家兔进行脑室内注入儿茶酚胺(CA),评估了儿茶酚胺在神经激素从下丘脑释放促性腺激素(GnHR)至垂体过程中的作用。脑室内注射剂量为200 - 500微克的6-OHDA会导致排卵暂时受阻。脑室内注入去甲肾上腺素(NA)可使50%的受试动物排卵,而多巴胺(DA)和肾上腺素(A)仅在极少数情况下诱导排卵。儿茶酚胺能系统似乎参与了神经激素向垂体的传递,且NA在此过程中起最重要作用。

相似文献

1
Role of catecholamines in release of gonadotrophic hormones in the rabbit.儿茶酚胺在兔促性腺激素释放中的作用。
Acta Physiol Pol. 1976 Mar-Apr;27(2):163-8.
2
[Effects of hypothalamic microinjections of 6-hydroxydopamine (6-OHDA) on estral cycle and morphology of the genital tract in the female rat (author's transl)].下丘脑微量注射6-羟基多巴胺(6-OHDA)对雌性大鼠发情周期和生殖道形态的影响(作者译)
Reproduccion. 1975 Apr-Jun;2(2):105-10.
3
The role of catecholamines in the regulation of gonadotropin secretion.儿茶酚胺在促性腺激素分泌调节中的作用。
Acta Morphol Hung. 1983;31(1-3):101-15.
4
Effects of intraventricular infusions of 6-hydroxydopamine (6-OHDA) on pituitary LH release and ovulation in the rabbit.脑室内注入6-羟基多巴胺(6-OHDA)对家兔垂体促黄体生成素释放及排卵的影响。
Neuroendocrinology. 1980 Jun;30(6):362-8. doi: 10.1159/000123035.
5
[Effect of neonatal 6-hydroxydopamine administration on the catecholaminergic structures of the hypothalamus and on the behavior of rats of various ages].[新生大鼠注射6-羟基多巴胺对下丘脑儿茶酚胺能结构及不同年龄大鼠行为的影响]
Ontogenez. 1989 May-Jun;20(3):332-6.
6
[Blockade of ovulation in rats by 6-hydroxydopamine].[6-羟基多巴胺对大鼠排卵的阻断作用]
Schweiz Med Wochenschr. 1971 Jul 31;101(30):1124-6.
7
[An electrophysiological approach to the gonadotropic function of the hypothalamus].
Arch Ital Biol. 1973 Dec;111(3-4):686-97.
8
[The role of various classes of catecholamines in the central regulation of the hypothalamo-hypophyseo-adrenal cortex system].
Fiziol Zh SSSR Im I M Sechenova. 1988 Sep;74(9):1316-20.
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[Blocking of ovulation with 6-hydroxydopamine].[用6-羟基多巴胺阻断排卵]
Bull Schweiz Akad Med Wiss. 1971 Sep;27(3):225-9.
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The effects of intraventricular 6-hydroxydopamine on body temperature and arterial blood pressure in cats and rabbits.脑室内注射6-羟基多巴胺对猫和兔体温及动脉血压的影响。
Br J Pharmacol. 1974 Jun;51(2):207-12. doi: 10.1111/j.1476-5381.1974.tb09648.x.

引用本文的文献

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Neuroendocrine control of gonadotropin-releasing hormone: Pulsatile and surge modes of secretion.神经内分泌对促性腺激素释放激素的调控:脉冲式和涌动式分泌。
J Neuroendocrinol. 2022 May;34(5):e13094. doi: 10.1111/jne.13094. Epub 2022 Feb 2.