Mourier J P
Cell Tissue Res. 1976 May 26;168(4):527-48. doi: 10.1007/BF00216001.
The mechanisms of cellular autophagy have been studied in the renal epithelium of male sticklebacks (Gasterosteus aculeatus L.) following castration. Two main types of alteration are described at the level of the proximal tubule cells. At first, the formation of endoplasmic reticulum whorls is observed, followed immediately by the secretion of lacunar progranules and by nucleolar modifications. These alterations lead to a progressive decrease of the glandular activity of the cells. The other main effect of castration is a general involution of the secretory granules still present in the cells. The involutive processes which lead to the complete destruction of the secretory material and, sometimes, of entire proximal cells, are described. In the collecting tubules, a marked and rapid decrease in glandular activity occurs, followed by disappearance of the mucous secretions. Small dense granules, supposedly lysosomes, are present. The processes described also appear to be characteristic of the normal involution of the renal cells occurring at the end of the breeding period. The findings strongly suggest that the male sex hormone may exert a double control on the renal cells in the stickleback, at both the cytoplasmic and nucleolar levels.
在雄性棘鱼（Gasterosteus aculeatus L.）去势后的肾上皮细胞中，对细胞自噬机制进行了研究。在近端小管细胞水平描述了两种主要类型的改变。首先，观察到内质网涡旋的形成，紧接着是腔隙性前颗粒的分泌和核仁的改变。这些改变导致细胞腺泡活性逐渐降低。去势的另一个主要影响是细胞中仍然存在的分泌颗粒普遍退化。描述了导致分泌物质完全破坏，有时导致整个近端细胞完全破坏的退化过程。在集合小管中，腺泡活性显著快速下降，随后粘液分泌物消失。存在小的致密颗粒，推测为溶酶体。所描述的过程似乎也是繁殖期结束时肾细胞正常退化的特征。这些发现有力地表明，雄性性激素可能在细胞质和核仁水平上对棘鱼的肾细胞发挥双重控制作用。
