Dupont E, Sansal I, Evrard C, Rouget P
Unité de Génétique Oncologique, CNRS-URA 1967, Institut Gustave Roussy, Villejuif, France.
J Neurosci Res. 1998 Jan 15;51(2):257-67. doi: 10.1002/(SICI)1097-4547(19980115)51:2<257::AID-JNR14>3.0.CO;2-5.
We have previously identified NPDC-1, a gene specifically expressed in neural cells and involved in the control of cell proliferation and differentiation. In the present study, we have investigated the expression of this gene during mouse development and the interactions of the NPDC-1 protein with cell cycle regulatory proteins. The data show that NPDC-1 mRNA begins to be expressed in a variety of neural structures when the precursors enter into their terminal differentiation. They also indicate that in adult brain, the expression patterns of NPDC-1 and E2F-1 mRNA largely overlap. In addition, the NPDC-1 protein is able to interact directly with the transcription factor E2F-1 that participates in the regulation of the cell cycle, cell survival, and apoptosis. The present results suggest that NPDC-1 might be involved in the terminal differentiation and survival of neural cells and might act through interactions with E2F-1.
我们之前已鉴定出NPDC-1，这是一个在神经细胞中特异性表达且参与细胞增殖和分化调控的基因。在本研究中，我们调查了该基因在小鼠发育过程中的表达情况以及NPDC-1蛋白与细胞周期调节蛋白的相互作用。数据显示，当前体进入终末分化时，NPDC-1 mRNA开始在多种神经结构中表达。数据还表明，在成体大脑中，NPDC-1和E2F-1 mRNA的表达模式在很大程度上重叠。此外，NPDC-1蛋白能够直接与参与细胞周期、细胞存活和凋亡调控的转录因子E2F-1相互作用。目前的结果表明，NPDC-1可能参与神经细胞的终末分化和存活，并可能通过与E2F-1相互作用发挥作用。
