Pitner J K, Long L D, Meyer R P, Pennypacker L C
Division of Geriatrics and Extended Care, Ralph H. Johnson V.A. Medical Center, and Medical University of South Carolina, Charleston 29401-5799, USA.
Pharmacotherapy. 1998 Jan-Feb;18(1):218-25.
Phenytoin toxicity occurred in an older man who received a dosage of 300 mg/day. The patient developed high serum phenytoin concentrations from this common adult dosage, with symptoms of functional decline and altered mental status. These behaviors were perceived as sun-downing and were treated with haloperidol. A long hospitalization was required.