de Haan P, Kalkman C J, Jacobs M J
Department of Anesthesiology, Academic Hospital, University of Amsterdam, The Netherlands.
Semin Thorac Cardiovasc Surg. 1998 Jan;10(1):19-24. doi: 10.1016/s1043-0679(98)70012-7.
Spinal cord ischemia during resection of thoracoabdominal aortic aneurysms (TAA) can result in lower limb neurological deficits. Spinal cord monitoring can only improve outcome if ischemia is detected before irreversible damage has occurred and protective measures are readily available. Monitorin( spinal cord function with motor evoked potentials (MEPs) is a relatively new technique. With MEP. recorded from the muscle (myogenic MEPs), the vulnerable spinal motoneuronal system is exclusively monitored and ischemia is detected within minutes. Using a strategy aimed at maintaining and restoring spinal cord blood supply (distal aortic perfusion, sequential aortic clamping, and selective segmental artery reattachment), early detection of ischemia allows protective measures to be applied and adjusted immediately, ie, reattaching or safely ligating intercostal arteries, increasing proximal o distal aortic pressures as required, or inducing hypothermia. Recent improvements in the technique fo eliciting myogenic MEPs include multi-pulse stimulation paradigms and the use of a circumferentia cathode. This results in robust and reproducible signals, which are less susceptible to anesthetic interference and allow the use of a constant level of neuromuscular blockade. In conclusion, monitoring myogenic MEPs during a TAA repair has become clinically feasible. The fast detection of spinal cord ischemia allows timely guidance of protective measures.
胸腹主动脉瘤(TAA)切除术中的脊髓缺血可导致下肢神经功能缺损。只有在不可逆损伤发生之前检测到缺血并且有可用的保护措施时,脊髓监测才能改善预后。用运动诱发电位(MEP)监测脊髓功能是一项相对较新的技术。通过记录肌肉的MEP(肌源性MEP),专门监测易损的脊髓运动神经元系统,并在数分钟内检测到缺血。采用旨在维持和恢复脊髓血供的策略(远端主动脉灌注、序贯主动脉阻断和选择性节段动脉再植),早期检测到缺血可使保护措施得以立即应用和调整,即重新连接或安全结扎肋间动脉,根据需要提高近端或远端主动脉压力,或诱导低温。近期在诱发肌源性MEP技术方面的改进包括多脉冲刺激模式和使用环形阴极。这产生了强大且可重复的信号,这些信号较不易受麻醉干扰,并允许使用恒定水平的神经肌肉阻滞。总之,在TAA修复术中监测肌源性MEP已在临床上可行。脊髓缺血的快速检测可及时指导保护措施。