Case M A, Ghadiri M R, Mutz M W, McLendon G L
Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.
Chirality. 1998;10(1-2):35-40.
The stereochemical consequences of the metal-ion assisted self-assembly of parallel three-helix peptide bundles are investigated. Chiral induction in the self-assembly of systems containing extensive protein secondary structure is compared with the racemic synthesis of short metallopeptides. Isolation and characterization of the individual stereoisomers of an exchange-inert metalloprotein provide structural insights into analogous exchange-labile systems.
研究了金属离子辅助平行三螺旋肽束自组装的立体化学后果。将含有广泛蛋白质二级结构的体系自组装中的手性诱导与短金属肽的外消旋合成进行了比较。对一种交换惰性金属蛋白的各个立体异构体的分离和表征为类似的交换不稳定体系提供了结构见解。
