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A short, stereoselective synthesis of (3R,4R)-4-acetoxy-3-[(R)-1'((t-butyldimethylsilyl)oxy)ethyl]-2-azetidin one, key intermediate for the preparation of carbapenem antibiotics.

作者信息

Cozzi F, Annunziata R, Cinquini M, Poletti L, Perboni A, Tamburini B

机构信息

Dipartimento di Chimica Organica e Industriale, Università di Milano, Italy.

出版信息

Chirality. 1998;10(1-2):91-4.

PMID:9470209
Abstract

A short stereoselective synthesis of the acetoxy azetidinone (1), an important precursor of several biologically active beta-lactam antibiotics, has been accomplished in seven steps and 32.8% overall yield from the easily available and inexpensive (R) ethyl 3-hydroxybutanoate.

摘要

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