以二糖和寡糖作为手性选择剂，在毛细管电泳中对阻转异构的1,1'-联萘-2,2'-二磷酸氢酯进行对映体拆分：毛细管电泳中的二糖和寡糖手性选择剂

Enantioseparation of atropisomeric 1,1'-binaphthyl-2,2'-diyl hydrogen phosphate in capillary electrophoresis by using di- and oligosaccharides as chiral selectors: di- and oligosaccharide chiral selectors in capillary electrophoresis.

作者信息

Chankvetadze B, Saito M, Yashima E, Okamoto Y

机构信息

Department of Applied Chemistry, School of Engineering, Nagoya University, Japan.

出版信息

Chirality. 1998;10(1-2):134-9.

PMID:9470211

Abstract

Twelve different disaccharides and a series of noncyclic malto- and cello-oligosaccharides were used as chiral selectors in capillary electrophoresis (CE). Most saccharides resolved the enantiomers of atropisomeric 1,1'-binaphthyl-2,2'-diyl hydrogen phosphate (BDHP) depending on the type (alpha or beta) and position of the linkage between monosaccharides. The effect of chain length of malto- and cello-oligosaccharides on enantioseparation of BDHP was also investigated. The nature of cations in background electrolytes affected significantly the separation of BDHP enantiomers.

摘要

十二种不同的二糖以及一系列非环状麦芽寡糖和纤维寡糖被用作毛细管电泳（CE）中的手性选择剂。大多数糖类根据单糖之间连接的类型（α或β）和位置，拆分了阻转异构的1,1'-联萘-2,2'-二磷酸氢酯（BDHP）的对映体。还研究了麦芽寡糖和纤维寡糖的链长对BDHP对映体拆分的影响。背景电解质中阳离子的性质显著影响了BDHP对映体的分离。