Bobrow L G, Millis R R, Happerfield L C, Gullick W J
Imperial Cancer Research Fund, Clinical Oncology Unit, Guy's Hospital, London, U.K.
Eur J Cancer. 1997 Oct;33(11):1846-50. doi: 10.1016/s0959-8049(97)00244-x.
c-erbB-3, A recently identified member of the type I tyrosine kinase receptor family, has been shown to be overexpressed in invasive ductal carcinoma of breast. In this study, expression of the c-erbB-3 protein was examined in 57 cases of pure ductal carcinoma in situ of the breast (DCIS) by immuno-cytochemical methods. Staining was either absent (17 cases), present at levels equivalent to that found in adjacent normal tissue (20) or greater than in normal tissue (20). In most cases the pattern of staining was cytoplasmic, but in 4 cases with the most intense reaction there was also focal membrane staining. In the same series of cases, c-erbB-2 protein had previously been shown to be overexpressed in 28 of 57 cases, c-erbB-2 overexpression was correlated with normal level of c-erbB-3, and lack of c-erbB-2 expression was correlated with c-erbB-3 overexpression.
c-erbB-3是I型酪氨酸激酶受体家族中最近发现的成员，已证实在乳腺浸润性导管癌中过度表达。在本研究中，采用免疫细胞化学方法检测了57例乳腺单纯原位导管癌（DCIS）中c-erbB-3蛋白的表达情况。染色结果为无染色（17例）、染色水平与相邻正常组织相当（20例）或高于正常组织（20例）。在大多数情况下，染色模式为细胞质染色，但在4例反应最强的病例中也有局灶性膜染色。在同一组病例中，先前已证实在57例中有28例c-erbB-2蛋白过度表达，c-erbB-2过度表达与c-erbB-3正常水平相关，而c-erbB-2表达缺失与c-erbB-3过度表达相关。
