Michel C, Cribier B, Sibilia J, Kuntz J L, Grosshans E
Clinique Dermatologique des Hôpitaux Universitaires de Strasbourg, France.
Br J Dermatol. 1997 Dec;137(6):958-62.
Many nail abnormalities have traditionally been described in association with rheumatoid arthritis (RA), but their specificity has never been assessed in a controlled study. Our purpose was to evaluate the frequency and the specificity of nail changes associated with RA in a case-controlled study including 50 patients suffering from RA and 50 controls. For each patient, a general skin examination was performed and the 20 nails were examined. The nail features were noted and classified. A chi 2 test or a Fisher test was used to compare the two groups. The only nail abnormalities significantly associated with RA were longitudinal ridging on nine or 10 finger nails (29 patients in the RA group vs. three in the controls, chi 2: P < 0.001) and clubbing on at least one nail (24 patients vs. 10, chi 2: P < 0.01). Other nail changes were noticed but were not frequent enough to be significant. The presence of longitudinal ridging on the finger nails was significantly associated with RA.
传统上，许多指甲异常都被描述为与类风湿关节炎（RA）相关，但从未在对照研究中评估过它们的特异性。我们的目的是在一项病例对照研究中评估与RA相关的指甲变化的频率和特异性，该研究包括50例RA患者和50名对照。对每位患者进行全面的皮肤检查，并检查20枚指甲。记录并分类指甲特征。使用卡方检验或费舍尔检验比较两组。与RA显著相关的唯一指甲异常是9枚或10枚手指甲出现纵嵴（RA组29例患者，对照组3例，卡方检验：P<0.001）以及至少一枚指甲出现杵状指（24例患者，对照组10例，卡方检验：P<0.01）。还注意到了其他指甲变化，但频率不足以具有显著性。手指甲出现纵嵴与RA显著相关。
