Whitfield M F, Barr D G
Arch Dis Child. 1976 May;51(5):337-43. doi: 10.1136/adc.51.5.337.
A girl with the syndrome of thrombocytopenia with absent radius had severe diarrhoea and dehydration relieved by withdrawal of cows' milk and aggravated by its reintroduction on three occasions. Deterioration in gastrointestinal symptoms was associated with haematological relapse with thrombocytopenia, leucocytosis, anaemia, and eosinophilia. There appeared to be a correlation between milk exposure and the haematological and gastrointestinal disturbances. Supporting evidence from published reports for such a correlation is reviewed. Cows' milk protein intolerance may be a factor in precipitating haematological relapse in susceptible infants with radius aplasia. Early withdrawal of cow's milk protein should be tried in thrombocytopenia with absent radius, especially in cases with prominent gastrointestinal upset.
一名患有桡骨缺如伴血小板减少综合征的女孩出现严重腹泻和脱水，停用牛奶后症状缓解，三次重新引入牛奶后症状加重。胃肠道症状的恶化与血液学复发相关，表现为血小板减少、白细胞增多、贫血和嗜酸性粒细胞增多。牛奶接触与血液学和胃肠道紊乱之间似乎存在关联。本文回顾了已发表报告中支持这种关联的证据。牛奶蛋白不耐受可能是导致患有桡骨发育不全的易感婴儿血液学复发的一个因素。对于桡骨缺如伴血小板减少的患儿，尤其是胃肠道不适明显的病例，应尝试早期停用牛奶蛋白。
