T细胞白血病蛋白SCL/tal-1在血管发育中存在未被发现的作用。
Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development.
作者信息
Visvader J E, Fujiwara Y, Orkin S H
机构信息
Division of Hematology-Oncology, Children's Hospital and the Dana Farber Cancer Center, Department of Pediatrics, and the Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
Genes Dev. 1998 Feb 15;12(4):473-9. doi: 10.1101/gad.12.4.473.
Abstract
The transcription factor SCL/tal-1 is essential for blood cell development. Though it is also expressed in vascular endothelium, SCL has been considered dispensable for vessel formation. Through transgenic rescue of hematopoietic defects of SCL-/- embryos and analysis of chimeras generated with SCL-/- ES cells tagged with a transgene expressed in vascular endothelial cells, we show that SCL is essential for angiogenic remodeling of the yolk sac capillary network into complex vitelline vessels. These findings establish a role for SCL in embryonic angiogenesis and argue for critical functions in both embryonic blood and vascular cells, the descendents of the presumptive hemangioblast.
摘要
转录因子SCL/tal-1对血细胞发育至关重要。尽管它也在血管内皮中表达，但SCL一直被认为对血管形成是可有可无的。通过对SCL-/-胚胎造血缺陷的转基因拯救以及对用在血管内皮细胞中表达的转基因标记的SCL-/-胚胎干细胞产生的嵌合体进行分析，我们发现SCL对于将卵黄囊毛细血管网络重塑为复杂的卵黄管是血管生成所必需的。这些发现确立了SCL在胚胎血管生成中的作用，并表明其在胚胎血液和血管细胞（假定成血管细胞的后代）中具有关键功能。
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