Zubovskaia A M, Ostrovskaia R U, Tsybina N M, Safronova M I
Biull Eksp Biol Med. 1976 May;81(5):539-41.
In examining the content of free ammonia, glutamine and some free amino acid s in the brain tissue of mice under normal conditions, in hypoxia and under the effect of succinic acidsemialdehyde, in hypoxia there was revealed a marked increase in comparison with the normal conditions) of the content of free ammonia, and alpha-alanine, a reduction of glutamine; there was also a slight elevation in the content of gamma aminobutyric acid and no changes in glutamic and asparagic acid content. In case of pretreatment with succinic acid semialdehyde the content of free ammonia, glutamine and alpha-alanine in hypoxia approached the normal value. One of the possible mechanisms of the antihypoxic effect of succinic acid semialdehyde was transformation of this compound as a results of which there occurred synthesis of glutamic acid and glutamine leading to detoxication of free ammonia accumulating in the brain tissue in hypoxia.
在检测正常条件下、缺氧状态下以及在琥珀酸半醛作用下小鼠脑组织中游离氨、谷氨酰胺和一些游离氨基酸的含量时发现，与正常条件相比，缺氧时游离氨和α-丙氨酸的含量显著增加，谷氨酰胺含量降低；γ-氨基丁酸含量也略有升高，谷氨酸和天冬氨酸含量无变化。在用琥珀酸半醛预处理的情况下，缺氧时游离氨、谷氨酰胺和α-丙氨酸的含量接近正常值。琥珀酸半醛抗缺氧作用可能的机制之一是该化合物的转化，其结果是发生了谷氨酸和谷氨酰胺的合成，从而导致缺氧时脑组织中积累的游离氨解毒。
