Voronova L A, Ivanov S D, Zabezhinskiĭ M A
Biull Eksp Biol Med. 1976 May;81(5):543-5.
The effect of chronic CCl4 treatment on both the liver RNA content and 3H-uridine incorporation was studied. Comparison of morphologic and biochemical parameters allowed to define two successive stages of toxic process resulting in septal fibrosis. The most significant changes in the rat liver rapid RNA turnover were observed during the first 3 months of the toxic agent action. The metabolic disturbances were also manifest in both decreased RNA content and changes of nuclear-cytoplasmic interrelationships in the damage liver tissue.
研究了慢性四氯化碳处理对肝脏RNA含量和3H-尿苷掺入的影响。通过比较形态学和生化参数，确定了导致间隔纤维化的毒性过程的两个连续阶段。在毒物作用的前3个月观察到大鼠肝脏快速RNA周转的最显著变化。代谢紊乱还表现为RNA含量降低以及受损肝组织中核质相互关系的改变。
