某些涉及视网膜色素上皮的动物和人类遗传性疾病中的电生理学。

Electrophysiology in some animal and human hereditary diseases involving the retinal pigment epithelium.

作者信息

Nilsson S E, Wrigstad A

机构信息

Department of Ophthalmology, University of Linköping, Sweden.

出版信息

Eye (Lond). 1997;11 ( Pt 5):698-706. doi: 10.1038/eye.1997.180.

DOI:10.1038/eye.1997.180

PMID:9474321

Abstract

The present paper surveys slow electrophysiological responses recorded by a d.c. technique in some hereditary eye diseases involving the retinal pigment epithelium (RPE) in animals (English setter dogs and Polish Owczarec Nizinny (PON) dogs with ceroid lipofuscinosis and Briard dogs with a slowly progressive rod-cone dystrophy associated with RPE inclusions) and in humans (Best's disease). The electroretinogram c-wave was typically either decreased in amplitude, lacking or replaced by a negative wave. These c-wave changes could be seen at fairly early stages of disease, when the a- and b-waves of the electroretinogram were still within normal limits.

摘要

本文综述了采用直流技术在一些遗传性眼病中记录到的缓慢电生理反应，这些眼病涉及动物（患有类脂褐质沉积症的英国塞特犬和波兰低地牧羊犬（PON）以及患有与视网膜色素上皮（RPE）包涵体相关的缓慢进行性视杆-视锥营养不良的伯瑞犬）和人类（Best病）的视网膜色素上皮（RPE）。视网膜电图c波的振幅通常要么降低、缺失，要么被负波替代。这些c波变化在疾病相当早期就能看到，此时视网膜电图的a波和b波仍在正常范围内。