Greenwald P, Woodard E, Nasca P C, Hempelmann L, Dayton P, Maksymowicz G, Blando P, Hanrahan L R, Burnett W S
Cancer. 1976 Jul;38(1):324-8. doi: 10.1002/1097-0142(197607)38:1<324::aid-cncr2820380147>3.0.co;2-q.
The present investigation was designed to test the admittedly speculative hypothesis that a factor involved in the etiology of human lymphatic and hematopoietic neoplasms may be transmitted by blood transfusion prior to the clinical onset of illness in the donor. One hundred and five New York State residents, who received blood from donors who subsequently developed neoplasms of the lymphatic or hematopoietic tissues, were identified and followed for an average period of 7.05 years. No recipient was found to have developed a leukemia or lymphoma following receipt of blood from a preleukemic or prelymphomatous donor. The results of this study should be considered priliminary because the small size of the recipient group might mask even a large increase in risk among the recipients.
本研究旨在检验一个公认的推测性假设，即人类淋巴和造血系统肿瘤病因中的一个因素可能在供血者临床发病前通过输血传播。确定了105名纽约州居民，他们接受了后来患淋巴或造血组织肿瘤的供血者的血液，并平均随访了7.05年。未发现接受白血病前期或淋巴瘤前期供血者血液的受血者患白血病或淋巴瘤。本研究结果应视为初步结果，因为受血者群体规模较小，可能掩盖了受血者中即使是大幅增加的风险。
