巨噬细胞-淋巴细胞相互作用与免疫反应性的遗传控制

Macrophage-lymphocyte interaction and genetic control of immune responsiveness.

作者信息

Thomas J W, Schroer J, Yokomuro K, Blake J T, Rosenthal A S

出版信息

Adv Exp Med Biol. 1979;121B:165-79. doi: 10.1007/978-1-4684-8914-9_15.

Abstract

We have reviewed briefly some of the diverse functions of macrophages in the immune response. Clearly, this population of cells interact physically with lymphoid cells, are required for activation of T cells, and process various protein antigens. Finally, we have studied the immune response to insulin in order to unify these previous data in such a way to demonstrate the active role of macrophages in the regulation of the immune response. The function of the Ir gene in the guinea pigs appears to be an intramolecular selection of discrete regions within the antigen for recognition by the T cell. The data presented suggest that this function operates at the level of the macrophage.

摘要

我们已简要回顾了巨噬细胞在免疫反应中的一些不同功能。显然，这群细胞与淋巴细胞发生物理相互作用，是T细胞激活所必需的，并且能处理各种蛋白质抗原。最后，我们研究了对胰岛素的免疫反应，以便以一种方式整合这些先前的数据，从而证明巨噬细胞在免疫反应调节中的积极作用。豚鼠中Ir基因的功能似乎是对抗原内离散区域进行分子内选择，以供T细胞识别。所呈现的数据表明，这一功能在巨噬细胞水平发挥作用。