de Asis M L, Rosenstreich D L, Chang C J, Gourevitch M N, Small C B
Department of Pediatrics, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York, USA.
Ann Allergy Asthma Immunol. 1998 Jan;80(1):35-8. doi: 10.1016/S1081-1206(10)62936-5.
Advanced HIV infection is associated with increased serum IgE levels, which in turn have been associated with a poor prognosis. Our preliminary data revealed that serum IgE levels were significantly elevated in HIV seropositive injection drug users compared with HIV seropositive non-injection drug users. Since viral hepatitis is common among injection drug users and is itself associated with elevated serum IgE levels, we studied whether there was an association between increased serum IgE levels and positive hepatitis serology in HIV-seropositive patients.
A retrospective cross-sectional analysis was performed. The medical records of ambulatory HIV-infected patients in an ongoing study were reviewed. Forty-five patients had hepatitis A, B, and C serology performed. The associations between serum IgE levels and hepatitis A, B and C antibodies, CD4 and CD8 lymphocyte percentages, injection drug use, and sex were analyzed by univariate and multiple regression analyses.
On univariate analyses, hepatitis B antibody was significantly associated with increased serum IgE levels in HIV-infected subjects (P = .013), especially in those with AIDS (P = .015). Multiple regression analyses controlling for CD4 lymphocyte percentages, sex, and drug use, confirmed that hepatitis B antibody status remained significantly associated with increased serum IgE levels (P = .05). There was no association of serum IgE levels with hepatitis A or C serology.
Prior hepatitis B infection is significantly associated with increased serum IgE levels in advanced HIV infection. The clinical implications of this finding deserve further study.
晚期HIV感染与血清IgE水平升高有关，而血清IgE水平升高又与预后不良相关。我们的初步数据显示，与HIV血清阳性的非注射吸毒者相比，HIV血清阳性的注射吸毒者血清IgE水平显著升高。由于病毒性肝炎在注射吸毒者中很常见，且其本身也与血清IgE水平升高有关，因此我们研究了HIV血清阳性患者血清IgE水平升高与肝炎血清学阳性之间是否存在关联。
进行回顾性横断面分析。对一项正在进行的研究中门诊HIV感染患者的病历进行了审查。45例患者进行了甲型、乙型和丙型肝炎血清学检查。通过单因素和多因素回归分析，分析了血清IgE水平与甲型、乙型和丙型肝炎抗体、CD4和CD8淋巴细胞百分比、注射吸毒情况及性别之间的关联。
单因素分析显示，在HIV感染患者中，乙型肝炎抗体与血清IgE水平升高显著相关（P = 0.013），尤其是在艾滋病患者中（P = 0.015）。在控制了CD4淋巴细胞百分比、性别和吸毒情况的多因素回归分析中，证实乙型肝炎抗体状态仍与血清IgE水平升高显著相关（P = 0.05）。血清IgE水平与甲型或丙型肝炎血清学无关联。
既往乙型肝炎感染与晚期HIV感染患者血清IgE水平升高显著相关。这一发现的临床意义值得进一步研究。
