Galasko G I
North Staffordshire City General Hospital, Stoke on Trent, UK.
J Cardiovasc Risk. 1997 Jun;4(3):185-90.
Cocaine usage goes back thousands of years, to the times of the Incas. Over the past 20 years, its use has increased dramatically, especially in America, and adverse cardiovascular reactions to the drug have begun to be reported. The first report of myocardial infarction temporally related to the recreational use of cocaine appeared in 1982. Since then, myocardial infarction has become recognized as the drug's most common cardiovascular consequence, with over 250 cases now documented in the literature. This review discusses the history of cocaine use, its pharmacology, the possible pathological mechanisms underlying the pathogenesis of myocardial ischaemia and infarction, and current ideas on the management of cocaine-induced myocardial infarction.
可卡因的使用可以追溯到数千年前印加时代。在过去20年里，其使用量急剧增加，尤其是在美国，并且已经开始有关于该药物不良心血管反应的报道。1982年首次出现了与可卡因娱乐性使用在时间上相关的心肌梗死报告。从那时起，心肌梗死已被公认为该药物最常见的心血管后果，目前文献中已有超过250例病例记录。本综述讨论了可卡因的使用历史、其药理学、心肌缺血和梗死发病机制背后可能的病理机制，以及目前关于可卡因诱导的心肌梗死管理的观点。
