Tárnoky A L, Bayliss V M, Bowen H J, Burnow R N, Sherington J
Clin Chim Acta. 1976 Jun 15;69(3):505-13. doi: 10.1016/0009-8981(76)90125-x.
Six tests recommended for use in the diagnosis of cystic fibrosis (CF) have been compared in the same subjects. The tests were carried out on 165 normal persons, 64 known cases of CF, their 67 parents and 18 sibs. The tests measured sodium in fingernails by activation, sodium in saliva and chloride in saliva and in thermal and pilocarpine-induced sweat by means of ion-specific electrodes, and chloride in pilocarpine-sweat by the standard titrimetric method. The tests ranged in complexity from simple screening methods to individual clinical procedures. None of the simpler tests matched the standard pilocarpine method in diagnostic efficiency, whether they were used singly or in combination.
对六项推荐用于诊断囊性纤维化（CF）的检测方法在同一批受试者中进行了比较。检测在165名正常人、64名已知CF患者、他们的67名父母以及18名同胞中进行。检测方法包括通过活化法测定指甲中的钠、用离子特异性电极测定唾液中的钠和氯以及热刺激和毛果芸香碱诱导汗液中的氯，并用标准滴定法测定毛果芸香碱汗液中的氯。这些检测方法的复杂程度从简单的筛查方法到个体化的临床操作不等。无论单独使用还是联合使用，没有一种较简单的检测方法在诊断效率上能与标准毛果芸香碱方法相匹配。
