Müller M, Schima W, Weissel M
Universitätsklinik für Innere Medizin III, Allgemeines Krankenhaus, Wien, Osterreich.
Wien Klin Wochenschr. 1997 Nov 28;109(22):887-9.
Amiodarone is an effective class-III antiarrhythmic agent. However, during long term therapy 1-10% of patients develop severe adverse pulmonary reactions, which are potentially life threatening. We report the case of a patient who developed dyspnoea and extensive pulmonary infiltrates compatible with amiodarone-associated interstitial lung disease following 6 months of treatment with amdiodarone (300 mg daily) for atrial flutter. On discontinuation of amiodarone treatment the infiltrates impressively resolved almost completely within 8 weeks, without administration of corticosteroids.
胺碘酮是一种有效的Ⅲ类抗心律失常药物。然而，在长期治疗期间，1%至10%的患者会出现严重的肺部不良反应，这些反应可能危及生命。我们报告了一例患者，该患者在接受胺碘酮（每日300毫克）治疗心房扑动6个月后，出现呼吸困难和广泛的肺部浸润，符合胺碘酮相关的间质性肺病。停用胺碘酮治疗后，肺部浸润在8周内几乎完全显著消退，未使用皮质类固醇。
