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佐剂诱导的大鼠炎性疾病：肽水解酶和蛋白酶抑制剂的血浆水平反映疾病活动。

Adjuvant-induced inflammatory disease in the rat: plasma levels of peptide hydrolases and protease inhibitors reflect disease activity.

作者信息

Schnebli H P

出版信息

Agents Actions. 1979 Dec;9(5-6):497-501. doi: 10.1007/BF01968118.

DOI:10.1007/BF01968118
PMID:94764
Abstract

Both during the primary (localized) inflammation and the development of the secondary (generalized) inflammation in adjuvant-treated rats, the plasma level of functional alpha-macroglobulins increases while proteases (measured as peptide hydrolases) sharply decrease. The decreased peptide hydrolase levels during episodes when protease 'spillage' into the bloodstream is elevated, suggests a more rapid clearance of alpha-macroglobulin-protease complexes associated with inflammation.

摘要

在佐剂处理的大鼠原发性（局部）炎症及继发性（全身性）炎症发展过程中，功能性α-巨球蛋白的血浆水平升高，而蛋白酶（以肽水解酶衡量）则急剧下降。当蛋白酶“漏入”血流增加时肽水解酶水平降低，这表明与炎症相关的α-巨球蛋白-蛋白酶复合物清除更快。

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Adjuvant-induced inflammatory disease in the rat: plasma levels of peptide hydrolases and protease inhibitors reflect disease activity.佐剂诱导的大鼠炎性疾病：肽水解酶和蛋白酶抑制剂的血浆水平反映疾病活动。
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引用本文的文献

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本文引用的文献

1
Determination of alpha-2-macroglobulin as trypsin-protein esterase.将α-2-巨球蛋白测定为胰蛋白酶-蛋白质酯酶。
Clin Chim Acta. 1966 Oct;14(4):493-501. doi: 10.1016/0009-8981(66)90037-4.
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Action of anti-inflammatory agents upon blood and histopathologic changes induced by periarthritis in rats.
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3
The alpha 1-antitrypsin and alpha 2-macroglobulin content and the protease-inhibiting capacity of normal and pathological sera.正常和病理血清中的α1-抗胰蛋白酶和α2-巨球蛋白含量以及蛋白酶抑制能力。
Clin Chim Acta. 1971 Jan;31(1):231-41. doi: 10.1016/0009-8981(71)90382-2.
4
Changes in liver lysosome fragility, erythrocyte membrane stability, and local and systemic lysosomal enzyme levels in adjuvant-induced polyarthritis.佐剂诱导的多关节炎中肝脏溶酶体脆性、红细胞膜稳定性以及局部和全身溶酶体酶水平的变化
Biochem Pharmacol. 1972 Mar 15;21(6):875-86. doi: 10.1016/0006-2952(72)90131-1.
5
Alpha 1-antitrypsin in serum and synovial fluid in rheumatoid arthritis.类风湿关节炎患者血清和滑液中的α1-抗胰蛋白酶
Ann Rheum Dis. 1974 Mar;33(2):162-4. doi: 10.1136/ard.33.2.162.
6
Lysosomal mechanisms of tissue injury in arthritis.关节炎中组织损伤的溶酶体机制
N Engl J Med. 1972 Jan 20;286(3):141-7. doi: 10.1056/NEJM197201202860307.
7
Rat alpha2-acute phase globulin, a human alpha2-macroglobulin homologue. Interaction with plasmin and trypsin.大鼠α2-急性期球蛋白，一种人α2-巨球蛋白同源物。与纤溶酶和胰蛋白酶的相互作用。
Biochim Biophys Acta. 1973 Sep 21;322(1):62-7. doi: 10.1016/0005-2795(73)90175-x.
8
Activation, inhibition and protection of tryptic and alpha-chymotryptic activity by normal human serum.
Clin Chim Acta. 1968 Apr;20(1):69-80. doi: 10.1016/0009-8981(68)90386-0.
9
Proteinase inhibitors in rheumatoid arthritis.类风湿关节炎中的蛋白酶抑制剂
Ann Rheum Dis. 1975 Jun;34(3):225-30. doi: 10.1136/ard.34.3.225.
10
On the inhibition of elastase by serum. Some distinguishing properties of alpha1-antitrypsin and alpha2-macroglobulin.关于血清对弹性蛋白酶的抑制作用。α1抗胰蛋白酶和α2巨球蛋白的一些区别特性。
Clin Chim Acta. 1975 Jul 9;62(1):43-53. doi: 10.1016/0009-8981(75)90278-8.