McClane T K, Martin W R
Clin Pharmacol Ther. 1976 Aug;20(2):192-8. doi: 10.1002/cpt1976202192.
These studies extend previous observations on the effects of pentobarbital on subjective states and postrotational nystagmus in postaddict subjects. Pentobarbital (150 mg) induced a degree of liking and an elevation of the morphine-benzedrine group (MBG) scale score equivalent to 24 mg of morphine. The effects of pentobarbital and meprobamate on postrotational nystagmus were studied using electro-oculography. Both drugs increased the frequency and prolonged the duration of postrotational nystagmus in a dose-related manner. Meprobamate was about 1/15 as potent as pentobarbital in enhancing postrotational nystagmus and producing signs of sedation.
这些研究扩展了先前关于戊巴比妥对成瘾后受试者主观状态和旋转后眼球震颤影响的观察结果。戊巴比妥（150毫克）引起了一定程度的喜好，并使吗啡-苯丙胺组（MBG）量表评分升高，相当于24毫克吗啡的效果。使用眼电图研究了戊巴比妥和甲丙氨酯对旋转后眼球震颤的影响。两种药物均以剂量相关的方式增加了旋转后眼球震颤的频率并延长了其持续时间。在增强旋转后眼球震颤和产生镇静迹象方面，甲丙氨酯的效力约为戊巴比妥的1/15。
