Chatterjie N, Sechzer J A, Lieberman K W, Alexander G J
New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA.
Pharmacol Biochem Behav. 1998 Feb;59(2):271-4. doi: 10.1016/s0091-3057(97)00528-5.
The locomotor stimulating effect of d-amphetamine in mice was counteracted by the administration of l-naloxone [(-)-naloxone], a known opiate receptor antagonist. Mice injected with amphetamine reached a peak locomotor activity within 30 min. When treated simultaneously with amphetamine and l-naloxone, these subjects showed low motility. Furthermore, when mice were treated not with l-naloxone but with its mirror image, d-naloxone [(+)-naloxone], a compound that by itself does not antagonize opiates and does not affect spontaneous motility, they showed no amphetamine-induced hyperactivity. The finding that an enantiomer of naloxone, with no opiate antagonist activity, is able to block the excitatory action of amphetamine, suggests the existence of a hitherto unknown mechanism of counteracting some of the effects of stimulants and euphoriants like amphetamine and cocaine.
已知的阿片受体拮抗剂左旋纳洛酮[(-)-纳洛酮]可抵消d-苯丙胺对小鼠的运动刺激作用。注射苯丙胺的小鼠在30分钟内达到运动活动峰值。当同时用苯丙胺和左旋纳洛酮处理时，这些小鼠表现出低运动性。此外，当小鼠不是用左旋纳洛酮而是用其镜像体右旋纳洛酮[(+)-纳洛酮]处理时，右旋纳洛酮本身不会拮抗阿片类药物且不影响自发运动性，这些小鼠未表现出苯丙胺诱导的多动。没有阿片拮抗剂活性的纳洛酮对映体能够阻断苯丙胺的兴奋作用，这一发现表明存在一种迄今未知的机制来抵消某些兴奋剂和致欣快剂（如苯丙胺和可卡因）的作用。
