Sasaki T, Maita E
Department of Dentistry, Nishitaga National Hospital, Sendai, Japan.
J Clin Periodontol. 1998 Jan;25(1):42-7. doi: 10.1111/j.1600-051x.1998.tb02362.x.
To elucidate the involvement of bFGF (basic fibroblast growth factor) in the pathogenesis of phenytoin-induced gingival overgrowth, we measured the concentration of bFGF in the serum of 36 epileptic patients taking phenytoin and in 94 normal volunteers by enzyme-linked immunosorbent assay technique. The concentration of phenytoin in serum was determined by high-performance liquid chromatography. In 34 of 36 patients taking phenytoin in this investigation, apparent gingival overgrowth was noticed. The mean concentration of bFGF was 33.9+/-18.5 pg/ml in the overgrowth group and 10.6+/-5.2 pg/ml in the volunteer group (p<0.01). The serum phenytoin level did not correlate (r=0.22, p=0.2) with the degree of gingival overgrowth but there was a significant correlation (r=0.38, p=0.023) between the degree of gingival overgrowth and the serum bFGF level. However, no correlation was observed among age, daily phenytoin dose, total phenytoin dose, duration of phenytoin therapy, serum phenytoin level, or serum bFGF level. The results suggested that enhanced serum bFGF level was implicated in the pathogenesis of phenytoin-induced gingival overgrowth.
为阐明碱性成纤维细胞生长因子（bFGF）在苯妥英钠所致牙龈增生发病机制中的作用，我们采用酶联免疫吸附测定技术，检测了36例服用苯妥英钠的癫痫患者及94名正常志愿者血清中bFGF的浓度。血清中苯妥英钠的浓度通过高效液相色谱法测定。在本次研究的36例服用苯妥英钠的患者中，有34例出现明显的牙龈增生。增生组bFGF的平均浓度为33.9±18.5 pg/ml，志愿者组为10.6±5.2 pg/ml（p<0.01）。血清苯妥英钠水平与牙龈增生程度无相关性（r=0.22，p=0.2），但牙龈增生程度与血清bFGF水平存在显著相关性（r=0.38，p=0.023）。然而，年龄、苯妥英钠日剂量、苯妥英钠总剂量、苯妥英钠治疗时长、血清苯妥英钠水平或血清bFGF水平之间均未观察到相关性。结果提示，血清bFGF水平升高与苯妥英钠所致牙龈增生的发病机制有关。
