Celada M M, Reguero J R, Cubero G I
Servicio de Cardiologia, Hospital Universitario Central de Asturias, Oviedo, Spain.
J Cardiovasc Risk. 1997 Aug;4(4):279-81.
Tobacco consumption is a major cardiovascular risk factor that has been related to changes in lipoprotein levels and in the leukocyte count.
To investigate the interrelationship among leukocytes, high-density lipoprotein (HDL) cholesterol levels and tobacco consumption.
In total 1022 healthy male miners aged 40.5+/-8 years (mean+/-SD) were evaluated consecutively during the period 1993-1994. We evaluated the smoking history of all of the subjects by means of a structured questionnaire. After the subject had fasted for 12 h we extracted blood samples by venepuncture. Plasma concentrations of HDL were determined enzymatically (by the CHOD-PAP method) and the leukocyte count was determined with an automatic analyser. Statistical analysis was performed using analysis of variance for the mean differences and the Pearson and stepwise tests to determine correlations.
The leukocyte count was significantly lower (8.014+/-2.327/mm3, P < 0.05) in those subjects with levels of HDL cholesterol equal to or greater than 0.9 mmol/l in comparison with that in those with HDL cholesterol levels lower than 0.9 mmol/l (8.450+/-2.375/mm3). Leukocyte counts were correlated directly to tobacco consumption (r= 0.3119, P < 0.01) and inversely to H DL cholesterol levels (r = -0.1513, P < 0.01). HDL cholesterol levels were lower in smokers (1.15+/-0.31 mmol/l) and these differences were significant with respect to the levels in non-smokers (1.22+/-0.30 mmol/l, P<0.05) but not with respect to those in former smokers (1.21+/-0.39 mmol/l). The leukocyte count was significantly greater in smokers (8.963+/-2.428/mm3, P<0.05) than it was in former smokers (7.041+/-1.698/mm3) and in non-smokers (6.793+/-1.599/mm3).
The results of this study indicate that tobacco consumption is associated with lower HDL cholesterol levels and higher leukocyte counts. Leukocyte counts correlate positively to tobacco consumption and inversely to HDL cholesterol levels. Subjects with HDL cholesterol levels lower than 0.9 mmol/l present with leukocyte counts higher than those found in those with HDL cholesterol values equal to or greater than 0.9 mmol/l.
烟草消费是主要的心血管危险因素，与脂蛋白水平和白细胞计数的变化有关。
研究白细胞、高密度脂蛋白（HDL）胆固醇水平与烟草消费之间的相互关系。
在1993年至1994年期间，对1022名年龄为40.5±8岁（均值±标准差）的健康男性矿工进行了连续评估。我们通过结构化问卷评估了所有受试者的吸烟史。受试者禁食12小时后，通过静脉穿刺采集血样。采用酶法（CHOD - PAP法）测定血浆HDL浓度，并用自动分析仪测定白细胞计数。使用方差分析均值差异以及Pearson检验和逐步检验来确定相关性进行统计分析。
HDL胆固醇水平等于或高于0.9 mmol/l的受试者白细胞计数（8.014±2.327/mm³，P < 0.05）显著低于HDL胆固醇水平低于0.9 mmol/l的受试者（8.450±2.375/mm³）。白细胞计数与烟草消费呈正相关（r = 0.3119，P < 0.01），与HDL胆固醇水平呈负相关（r = -0.1513，P < 0.01）。吸烟者的HDL胆固醇水平较低（1.15±0.31 mmol/l），与非吸烟者（1.22±0.30 mmol/l，P < 0.05）相比，这些差异具有统计学意义，但与既往吸烟者（1.21±0.39 mmol/l）相比无差异。吸烟者的白细胞计数（8.963±2.428/mm³，P < 0.05）显著高于既往吸烟者（7.041±1.698/mm³）和非吸烟者（6.793±1.599/mm³）。
本研究结果表明，烟草消费与较低的HDL胆固醇水平和较高的白细胞计数相关。白细胞计数与烟草消费呈正相关，与HDL胆固醇水平呈负相关。HDL胆固醇水平低于0.9 mmol/l的受试者白细胞计数高于HDL胆固醇值等于或高于0.9 mmol/l的受试者。
