Zárate A, Hernández M, Fonseca M E, Ochoa R
Unidad de Investigación de Enfermedades Endocrinas, Hospital de Especialidades del Centro Médico Nacional, Instituto Mexicano del Seguro Social, México DF.
Ginecol Obstet Mex. 1997 Dec;65:504-7.
Present study was designed to test that insulin resistance due to hyperinsulinism contribute to the clinical features of polycystic ovarian syndrome (POS). We studied 15 women wit POS who received Metformin 400 mg b.i.d during six months; blood levels of estradiol, testosterone (T), sexual hormone binding globulin (SHBG), insulin like growth factor-I (IGF-I) were determined. In response to treatment women exhibited decrement in serum levels of T as well as an increment, no significative, in both SHBG and IGF-I. Most of the patients showed reduction in body mass index and presented restoration of menstrual cycles. It is concluded that Metformin treatment exerts some metabolic effect which in turn induces some clinical improvement.
本研究旨在验证高胰岛素血症所致的胰岛素抵抗是否会导致多囊卵巢综合征（PCOS）的临床特征。我们研究了15名多囊卵巢综合征女性患者，她们在6个月内每天两次服用400毫克二甲双胍；测定了雌二醇、睾酮（T）、性激素结合球蛋白（SHBG）、胰岛素样生长因子-I（IGF-I）的血药浓度。经过治疗，女性患者的血清睾酮水平下降，而性激素结合球蛋白和胰岛素样生长因子-I水平虽有升高但无统计学意义。大多数患者体重指数降低，月经周期恢复正常。研究得出结论，二甲双胍治疗具有一定的代谢作用，进而带来了一些临床改善。
