不可抑制的胰岛素样活性对胰岛素降解的抑制作用。
Inhibition of insulin degradation by nonsuppressible insulin-like activity.
作者信息
Burghen G, Duckworth W C, Kitabchi A E, Solomon S S, Poffenbarger P L
出版信息
J Clin Invest. 1976 Apr;57(4):1089-92. doi: 10.1172/JCI108352.
Abstract
Nonsuppressible insulin-like activity, provided by three sources, was evaluated for its effect on the proteolytic degradation of insulin utilizing insulin protease obtained from rat liver homogenate as well as liver cell membranes. All three preparations of nonsuppressible insulin-like activity were found to be competitive inhibitors of insulin degradation. In addition human plasma was fractionated yielding an acetone precipitate which was found to have nonsuppressible insulin-like activity and to be a competitive inhibitor of insulin protease.
摘要
利用从大鼠肝脏匀浆以及肝细胞膜获得的胰岛素蛋白酶，对由三种来源提供的非抑制性胰岛素样活性进行了评估，以研究其对胰岛素蛋白水解降解的影响。发现所有三种非抑制性胰岛素样活性制剂都是胰岛素降解的竞争性抑制剂。此外，对人血浆进行了分级分离，得到一种丙酮沉淀物，发现其具有非抑制性胰岛素样活性，并且是胰岛素蛋白酶的竞争性抑制剂。
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