[Cytokines and extracellular matrix in experimental glomerulopathies].

An acute stage of both immune (nephrotoxic nephritis) and non-immune (puromycin-aminonucleoside nephrosis) damage is characterized by an affected area infiltration with mononuclear leucocytes which produce cytokines that control mesangial cells proliferation and their production of the extracellular matrix components. This mononuclear infiltration is very intensive in the immune kidney damage and rather weak in the non-immune damage. Accumulation of the extracellular matrix in a chronic stage of puromycin-aminonucleoside nephrosis is very slight against the background of a weak mononuclear infiltration of the kidney glomeruli. Nephrotoxic nephritis is characterized by intensive infiltration of a glomerulus with mononuclear leukocytes and this results in high proliferation of mesangial cells and an extracellular matrix accumulation with appearance of an atypical interstitial collagen of types I and III. The absence or excessive number of mononuclear leukocytes in the affected area may result in metabolism disturbances of the extracellular matrix components with an increasing risk of glomerulosclerosis.