Vorob'ev V V, Akhmetova E R, Kovalev G I
Institute of Cell Biophysics, Russian Academy of Sciences, Moscow Region, Russia.
Eksp Klin Farmakol. 1997 Sep-Oct;60(5):11-4.
Injection of N-methyl-D-aspartate (NMDA) into the brain of nonanesthetized and nonimmobilized rats with chronically implanted electrodes in the brain cortex and cannula in its lateral ventricle caused dose-dependent augmentation of low-frequency (0.5-2.5 Hz) and diminution of high-frequency (9-20 Hz) components of the ECG spectrum. The specific antagonist of nmm the NMDA-subtype glutamate/aspartate receptors CPP removed the effects on EEG of subsequent NMDA administration. The results of experiments with D- and L-glutamate are indicative of the receptor character of the NMDA effects of intensification of the slow EEG rhythm related to the appearance of seizure activity in the brain.
将N-甲基-D-天冬氨酸（NMDA）注射到大脑皮层植入慢性电极且侧脑室植入套管的未麻醉、未固定大鼠脑中，可导致心电图频谱低频成分（0.5 - 2.5赫兹）呈剂量依赖性增强，高频成分（9 - 20赫兹）减弱。NMDA亚型谷氨酸/天冬氨酸受体的特异性拮抗剂CPP消除了随后给予NMDA对脑电图的影响。用D-谷氨酸和L-谷氨酸进行的实验结果表明，NMDA增强与大脑癫痫活动出现相关的慢脑电图节律的作用具有受体特性。
