Palkovits M, Lovas G, Horváth E
Department of Anatomy, Semmelweis University Medical School, Budapest, Hungary.
Neuroscience. 1998 Apr;83(3):799-806. doi: 10.1016/s0306-4522(97)00451-x.
The binding sites of girisopam, a homophthalazine (2,3-benzodiazepine)-derivate have a specific distribution pattern restricted to the striato-pallido-nigral system of the rat brain. Following kainic acid lesions in the caudate-putamen or the ventral striatum (nucleus accumbens, olfactory tubercle), as well as after surgical transection of the striatonigral pathway, [3H]girisopam binding sites were reduced or completely eliminated from the substantia nigra and the entopeduncular nucleus. Kainic acid lesions of the globus pallidus failed to act on girisopam binding sites in the substantia nigra. Surgical transections or 6-hydroxydopamine lesions of the striatonigral pathway, as well as intranigral kainic acid injections did not influence binding sites in the striatum or the pallidum. These findings indicate that girisopam in the striatum to be postsynaptic on striatonigral projecting neurons. Girisopam in the striatum seems is present in striatonigral projecting neurons. The binding sites are transported from the striatum (mainly from the caudate-putamen, partly from the ventral striatum) to the substantia nigra and the entopeduncular nucleus. The exact identity of these striatonigral fibres bearing homopthalazines is uncertain.
吉利索泮是一种高邻苯二氮卓（2,3-苯并二氮杂卓）衍生物，其结合位点具有特定的分布模式，局限于大鼠脑的纹状体-苍白球-黑质系统。在尾状核-壳核或腹侧纹状体（伏隔核、嗅结节）进行 kainic 酸损伤后，以及在纹状体黑质通路进行手术横断后，黑质和内苍白球核中的[3H]吉利索泮结合位点减少或完全消失。苍白球的 kainic 酸损伤未能影响黑质中的吉利索泮结合位点。纹状体黑质通路的手术横断或 6-羟基多巴胺损伤，以及黑质内 kainic 酸注射均未影响纹状体或苍白球中的结合位点。这些发现表明，纹状体中的吉利索泮位于纹状体黑质投射神经元的突触后。纹状体中的吉利索泮似乎存在于纹状体黑质投射神经元中。结合位点从纹状体（主要来自尾状核-壳核，部分来自腹侧纹状体）运输到黑质和内苍白球核。这些携带高邻苯二氮卓的纹状体黑质纤维的确切身份尚不确定。
